Ketamine for Depression in Indiana

Spirvato is a nasal spray approved by the FDA that contains esketamine, derived from the drug ketamine. Studies have shown that ketamine is an effective drug for treating conditions like depression or PTSD. This treatment has been shown to work faster than other medications, with some patients seeing results in just a few hours, providing rapid relief. If you or a loved one has tried everything they can to manage their mental health or chronic pain disorder to no avail, ketamine therapy may help. The Indiana Center for Recovery is excited to offer this innovative treatment and help those with mood disorders get back to their living their life.

What is Ketamine?

Ketamine is a drug that has been approved for medical use by anesthesiologists at hospitals and vet clinics in high doses as a form of anesthetic during surgery. With that being said, Ketamine is sometimes used in an illegal manner to get high instead of for patient care. This drug acts on different chemicals in our brain, producing distortion both visually and with sound which allows the user to detach themselves from reality. Ketamine infusion therapy is another type of ketamine treatment that has not yet been approved.

What is Esketamine?

Esketamine is derived from the drug Ketamine and made into a dose far more potent. The theory on how ketamine produces antidepressant effects is that it works through the NMDA receptor leading to the growth of new nerve connections called synapses. Since this solution is more potent, patients can use this medication at lower doses so that they experience less side effects.




The Food and Drug Administration (FDA) approved a nasal spray in 2019 called Spravato, which contains esketamine. Medical professionals have begun using Spravato on their patients with major depressive disorder who are not having luck with other anti-depressant medications. However, this innovative drug is only available through a restricted distribution system with a certified medical private clinic where the patient is monitored carefully by a healthcare provider. Fortunately, Spravato is now available for patients at The Indiana Center for Recovery.

Treating Post-traumatic Stress Disorder (PTSD)

Post-traumatic stress disorder, also known as PTSD is a severe mental health condition in which an individual is triggered by a terrifying or traumatic event that happened whether they experienced it themselves or just witnessed it. This is a common condition among veterans who served in the war and can be significantly debilitating to the individual. It begins to affect their day-to-day life when the smallest of things trigger them and affects their ability to function. Evidence from a study conducted back in 2019 suggests that the way ketamine and esketamine interact with the human brain has the potential to lower symptoms of PTSD. The reason for this is that esketamine works as an antagonist to the N-methyl-D aspartate (NMDA) receptor.

For Treating Depression

Depression or major depressive disorder is a type of mood disorder that causes a chronic feeling of sadness or lack of interest. This condition can begin to interfere with an individual’s daily functions. Treatment-resistant depression refers to those who have tried other anti-depressant medications with no luck. Esketamine however, can provide relief from a major depressive disorder within just a few hours. Other medications used for major depression often take from days to weeks to begin working effectively. This relief in instance plays a huge role in managing symptoms of depressive disorder.

What to Expect From Ketamine Therapy

Just like ketamine, esketamine can significantly distort a person’s perception within the first couple of hours of the treatment. This is why it is so crucial this therapy is conducted under medical supervision. Treating depression with Spravato involves the patient coming in on an outpatient basis and giving themself three doses which are placed five minutes apart from each other.

This therapy also must be used while the patient is on traditional medication therapy. The purpose of this is to provide the patient with quick relief from depression, anxiety, PTSD, etc. until the other medication begins to work. What makes this treatment different from other medications used for depression is that standard anti-depressant medications work to increase serotonin, norepinephrine, and dopamine levels which are all naturally occurring chemicals in the brain.

Esketamine, however, works to increase the levels of glutamate which is one of the most prominent chemical messengers inside our brain. This allows more brain cells to be impacted at a single time.

Possible Side Effects

Different people’s bodies react to drugs in various ways. These side effects typically end about 2 hours after going through this treatment. The most intense symptoms will be experienced with the first two Spravato treatments.

Below is a list of common side effects of taking Spravato for depression:

Am I a Good Candidate for Spravato?

Your healthcare provider is the only person who can decide if Spravato is the treatment option for you. This therapy can be incredibly beneficial in helping a person get back to their life. It is important to understand what situations Spravato should not be taken. For example, those with a history of substance abuse are not recommended this therapy as it may create adverse effects.

Below are a few additional reasons this nasal spray may not be the right option:

Be open and honest with your healthcare provider so that they can adequately determine if Spravato is the right option for you.


Frequently Asked Questions (FAQ)

What is it like to use Ketamine if you have Asperger's Syndrome?

Ketamine users with Asperger’s syndrome have stated feeling more present at the moment with the correct dose. It has been described as feeling more sober than without the influence of drugs at all. With that being said, the effects of this drug can vary from person to person so this is not a guaranteed effect on all individuals with Asperger’s Syndrome.

What is Ketamine used for in the emergency room?

Ketamine is commonly used in emergencies room among doctors as well as vets as anesthesia to sedate patients during their surgery. The reason for this is the drug’s hypnotic, disassociation, and sedative properties. Ketamine treatment also has minimal effects on the cardiac output of the body. In lower doses, ketamine can significantly help with pain management.

Will insurance cover Sparvato treatment?

Whether Spravato treatments will be covered will depend on the insurance company as well as the condition of the patient. Most insurance companies will provide coverage for the nasal spray as long as it has been determined medically necessary by a professional.

How to help a chronically depressed person?

Helping someone who is chronically depressed can be frustrating when you are not sure how to approach the situation but still want to help. It is important to support your loved one if they are depressed and not force them to do anything they do not want to. Checking on them often and let them know you are there for them as much as you can also help. Encourage them to speak with their healthcare provider and be honest about how they are feeling so that the professional can guide them in the right direction toward relief.

What are the side effects that come with the use of ketamine?

Common side effects of taking Spravato include increased blood pressure, nausea, drowsiness, a feeling similar to being drunk, and headaches. This is why it is important that Spravato is taken under medical supervision in a clinic to prevent the health risks associated with ketamine. It is important to speak with your doctor or psychiatrist for medical advice and express all your concerns before going through this entire treatment cycle so that you get a proper diagnosis.