Spravato Ketamine Therapy: For Severe Depression and Anxiety

Spravato Ketamine Therapy is a new, FDA-approved breakthrough treatment option for people struggling with severe mental health issues, especially treatment-resistant depression. It delivers powerful, life-changing relief — often within hours, not weeks.

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What Is Spravato Ketamine Therapy?

Spravato Ketamine Therapy is a nasal spray made from esketamine, a form of ketamine that targets brain pathways untouched by typical antidepressants.

It’s FDA-approved specifically for adults with the official diagnosis of depression known as: Major Depressive Disorder. It is the only depression medication in the last 60 years that isn’t just a spinoff of existing antidepressants.

1 in 3 people do not experience a reduction in depressive symptoms taking antidepressants alone

Spravato Ketamine Therapy may also be used off-label for:

Bipolar disorder depressive episodes

Post-Traumatic Stress Disorder (PTSD)

Severe Anxiety Disorders

What to Expect During Spravato Ketamine Therapy

Spravato Ketamine Therapy has the potential to distort your perception during the first two hours, so it has to be administered in our certified treatment centers under the monitoring of trained medical staff to ensure you are safe, comfortable, and fully supported.

1 Spravato is similar to other nasal sprays you’ve used. You will administer the medication yourself under direct supervision, giving three doses spaced about five minutes apart.

2 After, you relax in a private room while the medication takes effect. Staff will monitor your vital signs and how you’re feeling. Most sessions last about two hours.

3 Usually, the treatment is given twice a week to start. If successful it is continued at decreased frequency depending on treatment response.

Spravato Ketamine Therapy is often combined with a traditional oral antidepressant. Spravato Ketamine Therapy provides rapid relief of depressive symptoms, so antidepressants can better help to maintain longer-term stability.

Key Benefits

FDA-approved to be safe
Fast-acting — feel better in hours or days
Effective for treatment-resistant depression
Works differently than antidepressants
Can work alongside existing medications
No long-term commitment or daily medication
The only medication besides lithium proven to decrease suicidal thoughts

Who Is Spravato Ketamine Therapy For?

The ideal candidate for Spravato has taken two or more oral antidepressants and still experiences symptoms of depression — known as Treatment-Resistant Depression (TRD).

Those living with intense depressive symptoms
People who haven’t felt better with traditional antidepressants
Patients seeking a new option when “trying harder” isn’t enough

Signs of Major Depressive Disorder

Depressed mood
Loss of interest in daily activities
Change in sleep, appetite or weight
Fatigue
Diminished concentration or slowed thoughts
Feelings of worthlessness

Is it Safe?

Spravato Ketamine Therapy here is carefully designed to be safe, structured, and patient-friendly.

FDA-approved and proven in clinical studies
Administered only at our certified treatment centers
Patients are monitored closely during and after each session

A rumor started that because ketamine is used as a veterinary medicine, it’s somehow unsafe for humans. In reality, many human medications are used in animals – including gabapentin, amoxicillin, and even Fluoxetine (Prozac). Ketamine has been used in humans at higher doses as Anesthesia since 1970, including for children’s surgeries.

Esketamine vs Ketamine

Spravato Ketamine Therapy technically uses esketamine, a refined part of the ketamine molecule. Esketamine is more targeted and potent, allowing it to work effectively at lower doses. The precision helps reduce the risk of side effects.

Spravato Ketamine Therapy Alternatives

From a medication standpoint, the only other FDA-approved option for treatment-resistant depression is a combination of olanzapine (an antipsychotic drug) and fluoxetine (a conventional antidepressant). These medications have serious long-term effects — including diabetes, substantial weight gain, metabolic changes, and high blood pressure. That said, Spravato Ketamine Therapy may not be right or work for everyone. That’s why we also offer gold-standard traditional therapies and cutting-edge medication-free treatments for mental health issues like Transcranial Magnetic Stimulation (TMS). You have plenty of options here to explore what actually works for you.

Where To Get Spravato Ketamine Therapy

Indiana Center for Recovery is one of few treatment centers in the Midwest offering Spravato. People fly from across the country to access cutting-edge mental health therapies that go well beyond ketamine therapy.

Other innovative options include TMS Treatment, GeneSight, EMDR Therapy, Biofeedback, and NAD+ IV Therapy – on top of gold-standard treatments like Cognitive Behavioral Therapy (CBT) and Motivational Interviewing (MI) and holistic options like art and music therapies.

It Starts With A Simple Call

If life feels unbearable, it’s time to find treatment that works. The team at Indiana Center for Recovery is ready to listen and offer innovative options you haven’t tried before — like Spravato Ketamine Therapy.

Hope and healing are closer than you think! Call today for the first step toward feeling like yourself again.

100% Confidential

No judgment

No commitment

Learn more about our mental health treatment options:

Mental Health Treatment

Whether you’re in mental health crisis or simply seeking to better your mental health — you can find relief here! Separated options for the highest-level hospitalizations to mid-tier residential rehab and outpatient programs.

Life-Changing Results Are Possible

I have tried more SSRIs and SNRIs than they gave the mice during testing of the drugs. On Spravato I’m finally weaning myself off of it. It works!

Anonymous

I was finally able to start Spravato and it has been life-changing. I felt positive effects after the first session and had the lowest PHQ score I’ve had in over 2 years.

Sigsegv0xb

I’m doing significantly better after only four treatments. It’s different for everyone, so the only way you’ll know is after trying it.

Squishy-lemons

Spravato Ketamine Therapy Is Covered By Insurance

Our doctors work with insurance companies to get coverage for Spravato Ketamine Therapy, so any cost to you is as low as possible — sometimes even zero. Find out more about your specific coverage upfront. No one will be notified if you reach out. And, there’s no commitment to get answers.

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