What to Expect During Spravato Ketamine Therapy
Spravato Ketamine Therapy has the potential to distort your perception during the first two hours, so it has to be administered in our certified treatment centers under the monitoring of trained medical staff to ensure you are safe, comfortable, and fully supported.
Spravato Ketamine Therapy is often combined with a traditional oral antidepressant. Spravato Ketamine Therapy provides rapid relief of depressive symptoms, so antidepressants can better help to maintain longer-term stability.
Key Benefits
- FDA-approved to be safe
- Fast-acting — feel better in hours or days
- Effective for treatment-resistant depression
- Works differently than antidepressants
- Can work alongside existing medications
- No long-term commitment or daily medication
- The only medication besides lithium proven to decrease suicidal thoughts
Who Is Spravato Ketamine Therapy For?
The ideal candidate for Spravato has taken two or more oral antidepressants and still experiences symptoms of depression — known as Treatment-Resistant Depression (TRD).
- Those living with intense depressive symptoms
- People who haven’t felt better with traditional antidepressants
- Patients seeking a new option when “trying harder” isn’t enough
Signs of Major Depressive Disorder
- Depressed mood
- Loss of interest in daily activities
- Change in sleep, appetite or weight
- Fatigue
- Diminished concentration or slowed thoughts
- Feelings of worthlessness
Is it Safe?
Spravato Ketamine Therapy here is carefully designed to be safe, structured, and patient-friendly.
- FDA-approved and proven in clinical studies
- Administered only at our certified treatment centers
- Patients are monitored closely during and after each session
A rumor started that because ketamine is used as a veterinary medicine, it’s somehow unsafe for humans. In reality, many human medications are used in animals – including gabapentin, amoxicillin and even Fluoxetine (Prozac). Ketamine has been used in humans at higher doses as Anesthesia since 1970, including for children’s surgeries.
Esketamine vs Ketamine
Spravato Ketamine Therapy technically uses esketamine, a refined part of the ketamine molecule. Esketamine is more targeted and potent, allowing it to work effectively at lower doses. The precision helps reduce the risk of side effects.
Spravato Ketamine Therapy Alternatives
From a medication standpoint, the only other FDA-approved option for treatment-resistant depression is a combination of olanzapine (an antipsychotic drug) and fluoxetine (a conventional antidepressant). These medications have serious long-term effects — including diabetes, substantial weight gain, metabolic changes, and high blood pressure.
That said, Spravato Ketamine Therapy may not be right or work for everyone. That’s why we also offer gold-standard traditional therapies and cutting-edge medication-free treatments for mental health issues like Transcranial Magnetic Stimulation (TMS). You have plenty of options here to explore what actually works for you.
Where To Get Spravato Ketamine Therapy
Indiana Center for Recovery is one of few treatment centers in the Midwest offering Spravato. People fly from across the country to access cutting-edge mental health therapies that go well beyond ketamine therapy.
Other innovative options include TMS Treatment, GeneSight, EMDR Therapy, Biofeedback and NAD+ IV Therapy – on top of gold-standard treatments like Cognitive Behavioral Therapy (CBT) and Motivational Interviewing (MI) and holistic options like art and music therapies.
Learn more about our mental health treatment options:

Whether you’re in mental health crisis or simply seeking to better your mental health — you can find relief here! Separated options for the highest-level hospitalizations to mid-tier residential rehab and outpatient programs.
Life-Changing Results Are Possible
I have tried more SSRIs and SNRIs than they gave the mice during testing of the drugs. On Spravato I’m finally weaning myself off of it. It works!
I was finally able to start Spravato and it has been life-changing. I felt positive effects after the first session and had the lowest PHQ score I’ve had in over 2 years.
I’m doing significantly better after only four treatments. It’s different for everyone, so the only way you’ll know is after trying it.
Spravato Ketamine Therapy Is Covered By Insurance
Our doctors work with insurance companies to get coverage for Spravato Ketamine Therapy, so any cost to you is as low as possible — sometimes even zero. Find out more about your specific coverage upfront. No one will be notified if you reach out. And, there’s no commitment to get answers.
Verify Your Insurance